what the vendor says
Both pypi.org and files.pythonhosted.org resolve into Fastly's published ranges (verified 2026-07-30: 151.101.0.223 and 151.101.128.223, inside 151.101.0.0/16), so pinning them would allowlist the whole CDN rather than PyPI.
Source: https://api.fastly.com/public-ip-list. That page is where this entry comes from, so you can check it rather than take our word for it.
what to do instead
Pick the control the vendor actually supports, and keep it scoped to the one workload that needs it:
- Verify the message, not the sender. Where a vendor signs its webhooks, checking the signature is stronger than an address check would have been, and it survives their infrastructure changing.
- Allow the hostname. Where a vendor publishes a stable domain, that needs something which resolves names: a proxy, a DNS firewall, or a network firewall rule group. A security group cannot do it.
- Contain the blast radius. Give that workload its own security group so the broad rule lives there and nothing else in the account inherits it. Coverage has a worked example.
the rest of your stack
One unpinnable dependency does not stop you pinning the others. The catalog covers the vendors that do publish official ranges, and the vendor report scores how well each one publishes.